RenoVō® is a liquid, acellular, equine amniotic tissue allograft comprised of amnion and amniotic fluid, intended to cover and protect tissues. It is cryopreserved and provided frozen in three volumes.
Item Number Size
RV-010150 1.5 cc
RV-010300 3.0 cc
RV-010500 5.0 cc
Amnion and amniotic fluid are rich sources of biologically active factors involved in tissue regeneration with reported anti-inflammatory, anti-bacterial, re-epithelialization, and anti-fibrotic properties1, 2. Amniotic tissues contain key growth factors, amino acid, hyaluronic acid, proteoglycans, and extracellular matrix proteins recognized as intrinsic to the complex tissue healing process.
Biological Factors Identified in RenoVō®
RenoVō® is enjoying rapid adoption as a superior alternative to autologous and other therapies. Ready availability of an allograft potentiates clinical use without having time lapse for culturing cells or harvest techniques required for PRP and other autologous therapies. Due to individual variability within products such as PRP, cytokine and growth factor profiles can vary dramatically between patients. The reproducibility of each donor tissue also offers a more homogeneous protein concentration and product consistency in comparison to other regenerative modalities. RenoVō® is cryopreserved and maintained frozen before use, to preserve beneficial proteins that may not survive lyophilization. Clinicians currently managing injuries with PRP or autologous therapy should consider use of RenoVō® to achieve similar or improved clinical outcomes.
Average total soluble protein concentration measured in RenoVō® (n=24, determined by a third party laboratory)
High Levels of Interleukin-1 Receptor Antagonist Protein (IRAP)
When comparing the average IL-1ra concentration to other modalities, the measured average IL-1ra concentration detected in RenoVō® was 12,406 pg/mL (n=24, determined by a third party laboratory) compared to 1,600 pg/mL in Pro-Stride, 8,200 pg/mL in IRAP-II, and 10,900 pg/mL in IRAP ProEAS (Arthrex® VetSystems, vLA1-000004-en-US_A)