Equine regenerative medicine is evolving quickly, and with that comes more choices. Two options you may be using or evaluating are PRGF (Plasma Rich in Growth Factors) and RenoVō®, an acellular equine amniotic tissue allograft. While both are used to support tissue, they are very different in their composition, preparation, and application.

Let’s take a closer look at what sets RenoVō® apart, especially when it comes to the power of amniotic tissue.

PRGF: Blood-Based, but Variable

PRGF is made from the horse’s own blood. After collection, the blood is spun in a centrifuge to isolate plasma rich in growth factors. While this technique is widely used, it comes with significant variability.

• The results depend on the horse’s blood quality that day.
• Centrifuge settings and technique affect what ends up in the final product.
• Some PRGF preparations include white blood cells, which may lead to irritation or inflammation.

This can make it difficult to ensure consistent outcomes from one case to the next.

RenoVō®: Biologically Rich and Consistent

RenoVō® is derived from equine amniotic tissue, specifically the amniotic fluid and membrane collected during healthy births. This natural source is rich in biologically active components that are beneficial for supporting and protecting tissues.

The amnion provides:

• IL-1ra (Interleukin-1 Receptor Antagonist) to help block pro-inflammatory signals.
• A2M (Alpha-2-Macroglobulin) which may help protect cartilage and bind damaging enzymes.
• TIMP-2 for tissue remodeling support.
• A broad set of extracellular matrix proteins and natural scaffolding elements.

RenoVō® is acellular, meaning it does not contain white or red blood cells. This helps reduce the risk of triggering an inflammatory response, making it an ideal option for veterinarians seeking a non-cell-based solution.

Why Cryopreservation Matters

RenoVō® is cryopreserved, not freeze-dried. This method helps preserve the biological activity of the proteins and growth factors found in amniotic tissue. There is no need for rehydration or extensive preparation.

• Stored frozen and ready to use.
• No centrifuge or mixing required.
• Each dose is aseptically processed and sterility tested for consistency and safety.

A Predictable Option for Equine Practices

In a busy clinic or in the field, having a product that is easy to use and delivers consistent results is key. RenoVō® helps reduce variability, save time, and support confident clinical decision-making. It offers a standardized formulation that can be administered without the complexity or variability that comes with blood-based products.

RenoVō® and PRGF are both used to support tissue health, but they are fundamentally different. RenoVō® offers the benefits of amnion-derived proteins, a consistent and acellular formulation, and simplified preparation. For equine veterinarians who value predictability, quality, and natural support, RenoVō® is a valuable addition to your regenerative care options.

To learn more or view clinical insights, visit renovoequine.com or reach out to our team.