Our Product

RenoVō^® is a liquid, acellular, equine amniotic tissue allograft comprised of amnion and amniotic fluid, intended to supplement and protect tissues.

RenoVō^® is cryopreserved and provided frozen in three volumes.

Item Number Size:
RV-010150 1.5 cc
RV-010300 3.0 cc
RV-010500 5.0 cc

Amnion and amniotic fluid are rich sources of biologically active factors involved in tissue regeneration with reported anti-inflammatory, anti-bacterial, re-epithelialization, and anti-fibrotic properties.^{1, 2} Amniotic tissues contain key growth factors, amino acid, hyaluronic acid, proteoglycans, and extracellular matrix proteins recognized as intrinsic to the complex tissue healing process.

RenoVō Equine Amniotic Tissue Allograft Product Package

Biological Factors Identified in RenoVō^®

RenoVō® is enjoying rapid adoption as a superior alternative to autologous and other therapies. Ready availability of an allograft potentiates clinical use without having time lapse for culturing cells or harvest techniques required for PRP and other autologous therapies. Due to individual variability within products such as PRP, cytokine and growth factor profiles can vary dramatically between patients. The reproducibility of each donor tissue also offers a more homogeneous protein concentration and product consistency in comparison to other regenerative modalities. RenoVō® is cryopreserved and maintained frozen before use, to preserve beneficial proteins that may not survive lyophilization. Clinicians currently managing injuries with PRP or autologous therapy should consider use of RenoVō® to achieve similar or improved clinical outcomes.

Functions & Proteins

Anti-Inflammatory

A2M

Alpha-2-Macroglobulin. Potent inhibitor of pro-inflammatory cytokines including IL-1, and non-specific protease inhibitors including matrix metalloproteinases responsible for cartilage degradation.

IL-1ra

Interleukin-1 Receptor Antagonist. Potent anti-inflammatory cytokine. Inhibits the activity of interleukin-1 related immune and inflammatory responses.

IL-10

Interleukin-10. Potent anti-inflammatory cytokine. Inhibits the activity of interleukin-10 inflammatory response.

Anti-Fibrotic

TIMP-2

Tissue Inhibitor of Metalloproteinases-2. Potent anti-fibrotic protein. Inhibitor of matrix metalloproteinases which are enzymes responsible for tissue destruction.

Immunomodulatory

MCP-1

Monocyte Chemoattractant Protein-1. Chemokine protein involved in the recruitment and activation of monocytes, memory T cells, and dendritic cells to sites of inflammation and injury.

IL-2

Interleukin-2. Cytokine that plays a central role in regulating immune responses.

IL-4

Interleukin-4. Cytokine that plays a central role in regulating immune responses.

Angiogenic

VEGF

Vascular Endothelial Growth Factor. Potent stimulator of angiogenesis and key player in wound healing and tissue regeneration.

Biological Factors Identified in RenoVō^®

Average total soluble protein concentration measured in RenoVō^® (n=24, determined by a third party laboratory)

Average Total Soluble Protein Concentration Graph

High Levels of Interleukin-1 Receptor Antagonist Protein

When comparing the average IL-1ra concentration to other modalities, the measured average IL-1ra concentration detected in RenoVō^® was 12,406 pg/mL (n=24, determined by a third party laboratory) compared to 1,600 pg/mL in Pro-Stride, 8,200 pg/mL in IRAP-II, and 10,900 pg/mL in IRAP ProEAS (Arthrex^® VetSystems, vLA1-000004-en-US_A)

The RenoVō^® Advantage

Image comparing RenoVo to other options for supporting equine health

References:
1. Amniotic Fluid: Not Just Fetal Urine Anymore. Mark A Underwood, William M Gilbert, Michael P Sherman. Journal of Perinatology. 2005; 25: 341-348

2. Growth factors and cytokines in wound healing. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Wound Repair Regen. 2008; 16(5): 585-601

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