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Alternative to PRP for Equines: Why Consider RenoVō®

By Bree Valensin, DVM

As equine veterinarians, we are often faced with navigating an overwhelming marketplace of biologics, supplements, and adjunctive therapies, each with varying levels of efficacy and practicality. In an industry saturated with countless products promising specialized benefits, finding something that genuinely delivers across multiple disciplines of care is rare.

RenoVo® has become one of those tools in my practice.

While many regenerative products are traditionally associated with soft tissue injury or joint maintenance alone, I have found RenoVo® demonstrates clinical utility far beyond those conventional applications. I have incorporated it into a wide range of therapeutic protocols, including ophthalmic support, nebulization therapy, and intravenous administration aimed at promoting overall systemic wellness and recovery. Having a single therapeutic option that is both accessible and adaptable across so many areas of care has proven truly invaluable.

What distinguishes RenoVo® most is its ability to integrate the most beneficial qualities of numerous regenerative and supportive therapies into one refined product. It simplifies that landscape without compromising clinical performance. Throughout my experience utilizing it in practice, I have observed meaningful improvements not only in recovery and athletic longevity, but also in the overall vitality and long-term health of my equine patients.

Perhaps most significantly, RenoVo® has proven especially valuable for aging horses and those affected by metabolic conditions where corticosteroid use may be limited or contraindicated altogether. These patients often require a far more nuanced and conscientious care strategy. Having a product that supports healing, comfort, and physiologic resilience without heavy reliance on steroids has been extraordinarily beneficial. Witnessing these horses maintain soundness, comfort, and quality of life well into their later years has been deeply rewarding.

To me, RenoVo® is an investment in the longevity, wellness, and sustained performance of the horses entrusted to our care.

 

About the Author

Bree Valensin, DVM is an equine veterinarian based in Weatherford, Texas and founder of Valensin Equine. She earned her veterinary degree from Midwestern University in Phoenix and brings extensive experience working with performance horses. She has incorporated RenoVo® into her therapeutic protocols at her discretion across a wide range of equine cases.

RenoVo® is a liquid, acellular, equine amniotic tissue allograft comprised of amnion and amniotic fluid, intended to supplement and protect tissues. Clinical decisions regarding its use are made at the discretion of the attending veterinarian.

Why RenoVō®? Alternative to PRP

Platelet-Rich Plasma (PRP) has been widely used in equine regenerative care, but it isn’t without its challenges. PRP preparations can vary significantly depending on blood quality, processing techniques, and the presence of white blood cells (WBCs), which sometimes trigger inflammation. This inconsistency can lead to unpredictable results, leaving veterinarians searching for a more reliable option.

RenoVō® offers a ready-to-use, standardized alternative without introducing the variability of PRP. Derived from equine amniotic tissue, RenoVō® provides a more consistent product containing beneficial proteins intrinsic to amniotic tissues like IL-1 receptor antagonist (IL-1ra), A2M, and TIMP-2— among others that are understood to reduce inflammation and support tissue health.

The Science Behind RenoVō®

While PRP relies on the activation of platelets to release growth factors for tissue repair, RenoVō® takes a different approach. It contains a combination of cytokines, growth factors, and anti-inflammatory proteins naturally found in amniotic tissue. Unlike PRP, RenoVō® is acellular, meaning it does not contain living cells like WBCs or RBCs that could trigger inflammation.

One key protein found in RenoVō® is IL-1ra (Interleukin-1 receptor antagonist), a protein that blocks the pro-inflammatory cytokine IL-1. This protein may help reduce inflammation at the site of implantation, creating a more favorable environment for tissue health. RenoVō® also includes A2M (Alpha-2-Macroglobulin) , TIMP-2, and other beneficial proteins that are understood to protect and support injured tissues.

For a deeper look at RenoVō®’s biological components, you can explore more here.

Consistency and Ease of Use

One of the biggest drawbacks of PRP can be in its inconsistency. PRP must be processed on-site, and the quality can vary based on blood collection, centrifugation techniques, and activation timing. This variability can lead to inconsistent outcomes, which is less than ideal when treating high-value horses.

RenoVō®, on the other hand, is aseptically processed, sterility tested, and ready to use right out of the package. This eliminates preparation time and ensures consistency across each batch. For busy equine veterinarians, RenoVō® simplifies use while delivering a large amount of beneficial proteins and a more predictable product.

Clinical Research & Real Applications

RenoVō®’s practical benefits and consistent outcomes are backed by both clinical research and real-world applications. Veterinarians have used RenoVō® successfully in countless cases.

If you’re interested in seeing how some Veterinarians are using RenoVō® in practice, take a look at:

Why RenoVō® Makes Sense

PRP has been a common tool in equine regenerative therapy, but its variability and potential for inflammation can limit its effectiveness. RenoVō® provides a standardized, acellular alternative that may reduce inflammation as compared to PRP, while delivering more consistent outcomes. Its ready-to-use formulation simplifies use for veterinarians, making it a practical choice for equine tissue support.

For veterinarians looking to provide reliable care without the challenges of PRP preparation, RenoVō® stands out as an advanced and effective option.

Learn more about RenoVō® by exploring our resources and studies. Have questions? We’re here to support you, contact us here.

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