As equine regenerative therapy evolves, veterinarians have more tools available to support tissue health. Two such products, RenoVō® and Alpha2EQ®, offer distinct biological compositions and clinical utility. Understanding their differences helps equine practitioners make informed decisions based on product composition, consistency, and ease of use.
Understanding the Core Difference
RenoVō® is a cryopreserved equine amniotic tissue allograft composed of acellular amnion and amniotic fluid. It contains growth factors, cytokines, extracellular matrix (ECM) components, exosomes, protease inhibitors, and immunomodulatory mediators. It is processed and packaged to supplement and protect tissues, and does not require preparation or processing on-site.
Alpha2EQ® is an autologous A2M concentrate, created from the horse’s own blood. It isolates alpha-2 macroglobulin (A2M), a protease inhibitor, through a process performed chairside by a veterinary professional.
Composition: Broad Spectrum vs. Targeted Protein
RenoVō® includes a complex mix of growth factors and cytokines such as IL-1ra, IL-10, A2M, TIMP-2, and MCP-1, along with ECM and exosomes. These components are naturally found in amniotic tissue and are understood to support biological pathways involved in tissue integrity.
Alpha2EQ® focuses solely on A2M, which is used to inhibit proteases and modulate catabolic activity in targeted tissues.
Key takeaway: RenoVō® provides a broader profile of biologics. Alpha2EQ® offers a single-protein approach that may be beneficial in specific clinical situations.
Consistency and Preparation
RenoVō® is aseptically processed, cryopreserved, and supplied in 1.5 cc, 3.0 cc, and 5.0 cc vials. It is ready for use immediately and requires no blood draw or on-site preparation.
Alpha2EQ® requires on-site blood collection and processing, which introduces variability based on the horse’s blood quality, preparation technique, and timing.
Veterinarians working in fast-paced or field-based settings may prefer a product that is consistently formulated and immediately available.
Inflammation Modulation
RenoVō® contains IL-1ra, IL-10, and A2M, which collectively support multi-pathway modulation of inflammation.
Alpha2EQ® delivers concentrated A2M, which focuses specifically on protease inhibition.
The additional presence of IL-1ra and IL-10 in RenoVō® may offer more comprehensive biological support for veterinarians looking to supplement and protect tissues using natural proteins found in amniotic tissue.
Structural Components and Tissue Environment
RenoVō® includes extracellular matrix proteins and exosomes, which are naturally present in amniotic tissue and are believed to contribute to tissue structure and protection.
Alpha2EQ® does not include structural components. It functions by providing targeted A2M for protease modulation.
ECM and exosomes may help support the environment surrounding healing tissues, which can be a consideration in clinical use.
Veterinary Considerations: Side-by-Side Summary
| Feature | RenoVō® | Alpha2EQ® |
|---|---|---|
| Type | Cryopreserved amniotic tissue allograft | Autologous A2M concentrate |
| Processing | Ready to use, no blood draw required | On-site blood collection and processing |
| Key Components | IL-1ra, IL-10, A2M, TIMP-2, ECM, exosomes | A2M |
| Consistency | Standardized per batch | Varies by individual horse and preparation method |
| Format | 1.5 cc, 3.0 cc, and 5.0 cc cryovials | Multi-dose, prepared in clinic |
| Inflammation Modulation | Multi-pathway (IL-1ra, IL-10, A2M) | A2M only |
Conclusion
RenoVō® and Alpha2EQ® each offer value depending on clinical goals. RenoVō® provides a broad spectrum of biologics, is consistent across batches, and is packaged for convenience. It contains a variety of naturally occurring factors found in amniotic tissues and is intended to supplement and protect tissues.
Alpha2EQ® may be appropriate for cases where a targeted A2M approach is desired and when on-site blood processing is feasible and preferred by the practitioner.
Veterinarians may choose either product based on case needs, logistical considerations, and product composition.
Want to Learn More?
Explore additional clinical information and product support at RenoVōEquine.com. Veterinarians can request to speak with peers who have used RenoVō® in practice to hear more about their experiences.
RenoVō® is labeled and marketed to supplement and protect tissues. It is not intended to diagnose, treat, cure, or prevent any disease. Off-label use is at the discretion of the attending veterinarian in accordance with regulatory guidelines and owner consent.
